Acta Stereologica Acta Stereologica -  Volume 18 (1999)  Number 1 - May 1999 

Angiogenesis evaluated with a new complexity measure

Haymo Kurz
Institute of Anatomy II, University of Freiburg, POB lll. D-79001 Freiburg, Germany
Jörg Wilting
Institute of Anatomy II, University of Freiburg, POB lll. D-79001 Freiburg, Germany
Bodo Christ
Institute of Anatomy II, University of Freiburg, POB lll. D-79001 Freiburg, Germany
Konrad Sandau
Faculty of Mathematics, FH Darmstadt, Schöfferstr 3, D-64295 Darmstadt, Germany

Abstract

Growth factor effects on blood vessel patterns were assessed with a fast and automated method that measures complexity (extended counting method: XCM; Sandau, 1996). XCM is a robust estimator of complexity not only in theory but also in practice: 1) it fulfills the quasi-maximum-property; 2) it shows reduced variance due to pattem translation and rotation; 3) it is less sensitive to image manipulations and thresholding. XCM is superior to traditional fractal analysis for detecting changes in vascular complexity following growth factor and control treatment.

Keywords : angiogenesis, avian embryo, blood vessel pattem, complexity, fractal, VEGF

To cite this article

Haymo Kurz, Jörg Wilting, Bodo Christ & Konrad Sandau, «Angiogenesis evaluated with a new complexity measure», Acta Stereologica [En ligne], Volume 18 (1999), Number 1 - May 1999, 27-32 URL : https://popups.ulg.ac.be/0351-580x/index.php?id=62.