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- Quantification of three-dimensional vascular patterns in renal glomeruli
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Quantification of three-dimensional vascular patterns in renal glomeruli
Abstract
A method is developed for quantitative characterization of 3D capillary networks. Volume data was obtained by stacking up confocal epifluorescent images of renal glomeruli with a Zeiss CLSM. To provide the 3D data set, a region of interest containing an entire glomerulus was extracted from the volume data. A reconstruction of a capillary network with nodes representing transversal profiles of capillary lumens is made by applying a node-branch model of 3D vascular patterns. This network is used to derive the connectivity of the 3D vascular structure and the length and number of capillaries.
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About: Elźbieta Kaczmarek
Department of Cellular Pathology, Armed Forces Institute of Pathology, Washington, D.C. 20306-6000, USA