Acta Stereologica

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Emilio Artacho-Pérula & Rafael Roldán-Villalobos

Quantitative analysis of nuclear volume and size variability of breast samples

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Abstract

Two stereological methods recently developed for the estimation of the mean volume of particles are applied to normal breast samples and to invasive ductal breast carcinomas with the aim to evaluate the efficiency of these unbiased estimates and to obtain a real size variability of the nuclei. Both volume-weighted and number-weighted mean nuclear estimates demonstrate a high capacity for differentiating between normal and pathological lesions. A good correlation between different estimates of the mean nuclear volume is found. The information concerning nuclear size variability reveals a significant increase from normal to invasive ductal breast samples when the coefficient of variation of nuclear volume CVN(v) was derived from independent estimates of number-weighted ('selector' method) and volume-weighted (‘point- sampled intercepts‘ method) mean nuclear volume. The study shows that efficiency of the volume-weighted mean nuclear volume estimates was higher than that of the number-weighted ones.

Keywords : breast, nuclear volume, point-sampled intercepts, selector, size variability

To cite this article

Emilio Artacho-Pérula & Rafael Roldán-Villalobos, «Quantitative analysis of nuclear volume and size variability of breast samples», Acta Stereologica [En ligne], Number 2 - Applications of stereology in life sciences - July 1996, Volume 15 (1996), 111-118 URL : https://popups.ulg.ac.be/0351-580x/index.php?id=495.

About: Emilio Artacho-Pérula

Department of Morphological Sciences (Section of Histology), School of Medicine, University of Córdoba, Avda. Menéndez Pidal s/n, 14071 Córdoba, Spain

About: Rafael Roldán-Villalobos

Department of Morphological Sciences (Section of Histology), School of Medicine, University of Córdoba, Avda. Menéndez Pidal s/n, 14071 Córdoba, Spain