Acta Stereologica

0351-580X

 

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Pierre R. Filion & Michel G. Côté

Volumetric evaluation of pulmonary alveolar toxicity: the BHT model

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Abstract

Butylated hydroxytoluene (BHT) provides a good model of toxicity to the pulmonary alveolar epithelium of mice. The volume fraction (Vv) of each epithelial cell type is determined by volumetric analysis, using point counting on electron micrographs of mice treated with a combination of BHT and oxygen. BHT is the major influence in inducing the degeneration of type I pneumocytes, early (days 1 to 3) after its administration. These lesions in turn trigger epithelial regeneration (at days 3 to 5), effected by type II pneumocytes. The most sensitive index of epithelial modifications is found in the Vv of the intermediate type cell, which represents the transformation of type II into type I cells. Addition of a high concentration of oxygen (95%) for 24 hours does not much enhance this toxicity, but hastens epithelial regeneration by the type II pneumocyte.

Pour citer cet article

Pierre R. Filion & Michel G. Côté, «Volumetric evaluation of pulmonary alveolar toxicity: the BHT model», Acta Stereologica [En ligne], Volume 2 (1983), Number 1 - Apr. 1983, 89-99 URL : https://popups.ulg.ac.be/0351-580x/index.php?id=4099.

A propos de : Pierre R. Filion

Département de pharmacologie, Faculté de médecine, Université de Montréal, Montréal, Canada, H3C 3J7

A propos de : Michel G. Côté

Département de pharmacologie, Faculté de médecine, Université de Montréal, Montréal, Canada, H3C 3J7