Acta Stereologica Acta Stereologica -  Volume 17 (1998)  Number 3 - Dec. 1998 

Volume-weighted mean nuclear volume in dysplastic glands from the ventral prostate of rats treated with cadmium chloride, and resembling human prostatic intraepithelial neoplasia

Luis Santamaría
Department of Morphology (Histology), School of Medicine, Autonomous University of Madrid, Spain
Rocío Martín
Department of Pathology (Hospital de La Princesa), School of Medicine, Autonomous University of Madrid, Spain
José J. Martín
Department of Anaesthesiology, Hospital Ramón y Cajal, Madrid, Spain

Abstract

Estimates of volume-weighted mean nuclear volume have been perfoimed in dysplastic epithelium from ventral prostate of rats treated with chronic oral exposure to cadmium chloride. The nuclear size of dysplastic cells was significantly increased in compaiison to both controls and treated non-dysplastic acini. The high variability detected in the lowest level of sampling for the measurements of dysplastic glands may be due to the important hetereogeneity of their nuclei, similar to that observed in human prostatic intraepithelial neoplasia. The estimation of nuclear Vv, could prove interesting to study the behaviour of both neoplastic and pre-neoplastic lesions in experimental carcinogenesis as it has been stated for human tumors.

Keywords : cadmium chloride, dysplastic glands, human prostatic intraepithelial neoplasia, rats, ventral prostate, volume-weighted mean nuclear volume

To cite this article

Luis Santamaría, Rocío Martín & José J. Martín, «Volume-weighted mean nuclear volume in dysplastic glands from the ventral prostate of rats treated with cadmium chloride, and resembling human prostatic intraepithelial neoplasia», Acta Stereologica [En ligne], Volume 17 (1998), Number 3 - Dec. 1998, 377-382 URL : https://popups.ulg.ac.be/0351-580x/index.php?id=353.