Acta Stereologica

0351-580X

 

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Klaus Kayser, Bernd Kiefer, Hans Ulrich Burkhardt & Margit Shaver

Syntactic structure analysis of bronchus carcinomas – First results

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Abstract

Histopathology of 100 cases of operated lung carcinoma patients was analysed by syntactic structure analysis. Material consisted of HE-stained paraffin embedded sections of 20 cases of healthy lung parenchyma, and 20 cases of each of the four major cell types of bronchus carcinomas respectively (epidermoid, adeno, small cell, large cell carcinomas). Network formed by epithelial cells, mean distance of cell centers, distribution of distances according to neighborhood sequences were measured using programms written in BASIC. O'Callaghan's (1975) neighborhood condition was used. Reclassification of 75 cases using discriminant analysis was performed with programms from SPSS retrospectively, whereas 25 cases were classified prior to final diagnosis. Correct reclassification could be performed in 68/75 cases (87%) retrospectively and in 23/25 prospectively. All cases with healthy lung parenchyma could be separated correctly. Analysis of network pattern revealed similar textures of epidermoid carcinomas and of small cell anaplastic carcinomas in some cases, and of adeno carcinomas compared to large cell carcinomas in some cases respectively in accordance with similar difficulties obtained by pathologists.

Keywords : bronchus carcinoma, diagnostic algorithm, syntactic structure analysis

To cite this article

Klaus Kayser, Bernd Kiefer, Hans Ulrich Burkhardt & Margit Shaver, «Syntactic structure analysis of bronchus carcinomas – First results», Acta Stereologica [En ligne], Volume 4 (1985), Number 2 - Proceedings of the fourth European symposium for stereology - Dec. 1985, 249-253 URL : https://popups.ulg.ac.be/0351-580x/index.php?id=3271.

About: Klaus Kayser

Institute of Pathology, University of Heidelberg, Ira Neuenheimer Feld 220/221, D-6900 Heidelberg, FRG

About: Bernd Kiefer

Institute of Pathology, University of Heidelberg, Ira Neuenheimer Feld 220/221, D-6900 Heidelberg, FRG

About: Hans Ulrich Burkhardt

Institute of Pathology, University of Heidelberg, Ira Neuenheimer Feld 220/221, D-6900 Heidelberg, FRG

About: Margit Shaver

Institute of Pathology, University of Heidelberg, Ira Neuenheimer Feld 220/221, D-6900 Heidelberg, FRG