Acta Stereologica

0351-580X

 

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Gerhard Mall, Hans-Jörg Möbius, Torsten Mattfeldt & Rainer Leonhard

Ultrastructural morphometric study on the rat heart in chronic alimentary thiamine deficiency

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Abstract

Male Wistar rats were fed with a thiamine-free diet for 35 days. The growth of the thiamine-deficient animals was considerably suppressed, as compared to a pair-fed control group (body weights: 140.4 ±4.3 g versus 243.1 ± 4.3 g). A weight-matched control group was, therefore, evaluated in addition. Histologic and ultrastructural investigations of the hearts did not reveal any morphologic abnormalities. Morphometric analysis was performed on left ventricular papillary muscles and disclosed significant differences of stereologic parameters ("densities") between the thiamine-deficient group and the control group, but no differences were detected between the thiamine-deficient group and the weight-matched control group. It is concluded that stereologic parameters ("densities") of the myocardium depend on the body weight and on the heart weight, respectively, and that our experimental model of thiamine-deficiency was associated with a normal structure of the myocardium.

Keywords : myocardium, stereology, thiamine deficiency, ultrastructure

Om dit artikel te citeren:

Gerhard Mall, Hans-Jörg Möbius, Torsten Mattfeldt & Rainer Leonhard, «Ultrastructural morphometric study on the rat heart in chronic alimentary thiamine deficiency», Acta Stereologica [En ligne], Volume 4 (1985), Number 2 - Proceedings of the fourth European symposium for stereology - Dec. 1985, 217-222 URL : https://popups.ulg.ac.be/0351-580x/index.php?id=3225.

Over : Gerhard Mall

Institute of Pathology, University of Heidelberg, Im Neuenheimer Feld 220/221, D-6900 Heidelberg, F.R.G.

Over : Hans-Jörg Möbius

Institute of Pathology, University of Heidelberg, Im Neuenheimer Feld 220/221, D-6900 Heidelberg, F.R.G.

Over : Torsten Mattfeldt

Institute of Pathology, University of Heidelberg, Im Neuenheimer Feld 220/221, D-6900 Heidelberg, F.R.G.

Over : Rainer Leonhard

Institute of Pathology, University of Heidelberg, Im Neuenheimer Feld 220/221, D-6900 Heidelberg, F.R.G.