- Startpagina tijdschrift
- Volume 10 (1991)
- Number 2 - Stermat '90 (part II) - Dec. 1991
- Ultrastructural markers of tubular transport in acute experimental renal ischemia, evaluation of the proximal and distal tubules
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Ultrastructural markers of tubular transport in acute experimental renal ischemia, evaluation of the proximal and distal tubules
Abstract
The study was carried out on rats. Electron micrographs of the kidney obtained from the proximal and distal tubules in acute experimental renal ischemia were analysed. Using stereological methods to estimate of ultrastructural markers of active transport (mitochondrial energy states), and passive transport (intercellular spaces and basal infolded channels) were evaluated. The results obtained indicated that in the proximal and distal tubules following acute renal ischemia, active transport was impaired as reflected by a lowering of mitochondrial energy states (similar to condensed). Widening of intercellular spaces and basal infolded channels was also observed, which suggests fluid stasis and, thus, impairment of passive transport.