Acta Stereologica

0351-580X

 

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Italo Bearzi, Renzo Ranaldi, Banafsheh Rezai, Corrado Sassaroli & Bruno Mannello

AgNORs and PCNA immunoreactivity in early and advanced gastric carcinoma

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Abstract

In order to point out differences in the biological behaviour between early and advanced gastric carcinoma, their proliferative activity is evaluated on paraffin sections by silver staining of NOR particles and by immunohistochemical detection of PCNA. AgNOR particles were measured by a Leitz-Texture Analyzing System. The following variables were considered: nuclear area; area, number and percentage area of AgNOR; mean area of each AgNOR particle. The percentage of PCNA-positive nuclei was calculated. The results failed to show any significant difference of EGC compared to AGC. The possibility that differences in biological behaviour, other than the proliferative activity, could exist between EGC and AGC, is discussed.

Keywords : AgNOR, early gastric cancer, PCNA, proliferative activity

To cite this article

Italo Bearzi, Renzo Ranaldi, Banafsheh Rezai, Corrado Sassaroli & Bruno Mannello, «AgNORs and PCNA immunoreactivity in early and advanced gastric carcinoma», Acta Stereologica [En ligne], Volume 11 (1992), Number 1 - Quantitative histopathology - Aug. 1992, 119-124 URL : https://popups.ulg.ac.be/0351-580x/index.php?id=1870.

About: Italo Bearzi

Institute of Pathology, University of Ancona, Ospedale Nuovo Regionale, 60020, Torrette di Ancona, Italy

About: Renzo Ranaldi

Institute of Pathology, University of Ancona, Ospedale Nuovo Regionale, 60020, Torrette di Ancona, Italy

About: Banafsheh Rezai

Institute of Pathology, University of Ancona, Ospedale Nuovo Regionale, 60020, Torrette di Ancona, Italy

About: Corrado Sassaroli

Institute of Pathology, University of Ancona, Ospedale Nuovo Regionale, 60020, Torrette di Ancona, Italy

About: Bruno Mannello

Institute of Pathology, University of Ancona, Ospedale Nuovo Regionale, 60020, Torrette di Ancona, Italy