Acta Stereologica

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Hannu Haapasalo

Volume corrected mitotic index (m/v index) in ovarian cancer

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Abstract

The M/V index expresses the mitotic activity of epithelial cancer as the number of mitotic figures per square millimeter of neoplastic epithelium in the microscope field. The M/V index is less subject to variation in the amount of neoplastic epithelium between neoplasms or in size of the microscope field than conventional mitotic index (mitoses/high power fields). In ovarian cancer, the mitotic activity had the best reproducibility among histoquantitative variables between different observers and laboratories. The M/V index was the best morphometric predictor in ovarian cancer in 105 cases studied. The prognostic value of two histological and two morphometric grading methods was inferior to that of the M/V index. Morphometric grading methods were better reproducible than subjective histological grading. In Cox's regression analysis the clinical stage (FIGO), the M/V index, and nuclear DNA content had independent prognostic value. Tumour ploidy emerged as the only independent predictor in advanced ovarian carcinoma. The M/V index was the best predictor of prognosis in stage I ovarian carcinoma.

Keywords : static DNA cytometry, mitotic index, morphometry, ovary carcinoma

To cite this article

Hannu Haapasalo, «Volume corrected mitotic index (m/v index) in ovarian cancer», Acta Stereologica [En ligne], Volume 11 (1992), Number 1 - Quantitative histopathology - Aug. 1992, 89-98 URL : https://popups.ulg.ac.be/0351-580x/index.php?id=1834.

About: Hannu Haapasalo

Department of Pathology, Tampere University Hospital, SF-33520 Tampere, Finland