Acta Stereologica

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Stefano Sisti, Alfredo Santinelli, Mirca Valli, Roberta Taborro, Bruno Mannello & Gianmario Mariuzzi

Quantitative methods in histopathology: evaluation of their prognostic power in infiltrating ductal breast carcinoma

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Abstract

The value of quantitative histopathologic analysis in prognosis of infiltrating ductal breast carcinoma was assessed. The study was carried out on breast tumours at an early clinical stage, with diameters below 2.5 cm. Ninety cases were studied. At the end of the study there were 45 deceased and 45 surviving patients, the latter with a follow-up of at least 69 months. Quantitative histopathologic analysis was carried out by simultaneously measuring a number of geometric features in the nuclei and nucleoli of each tumour. In addition, mitotic activity and the percentage of immunohistochemically positive cells for proliferating cell nuclear antigen (PCNA) were recorded in each case. The study showed many statistically significant differences (p < 0.05) between the two groups of deceased and surviving patients. However, very few differences were observed when the groups of patients with and without axillary lymph node metastases were compared. Moreover, no significant differences were found between deceased patients with short (≤ 30 months) and long (> 30 months) survival. With multivariate analysis (forward stepwise discriminant analysis) it was possible to produce a canonical discriminant function by which the deceased and surviving patients were correctly classified in 92.2% of the cases. The results stress the usefulness of quantitative methods in the prognostic assessment of breast cancer, as well as the possibility of applying this approach to cytologic material, in order to preoperatively identify patients at high risk for death.

Keywords : breast cancer, image analysis, immunohistochemistry, prognosis, quantitative pathology

To cite this article

Stefano Sisti, Alfredo Santinelli, Mirca Valli, Roberta Taborro, Bruno Mannello & Gianmario Mariuzzi, «Quantitative methods in histopathology: evaluation of their prognostic power in infiltrating ductal breast carcinoma», Acta Stereologica [En ligne], Volume 11 (1992), Number 1 - Quantitative histopathology - Aug. 1992, 79-88 URL : https://popups.ulg.ac.be/0351-580x/index.php?id=1824.

About: Stefano Sisti

Department of Pathology, University of Ancona, Ospedale Nuovo Regionale, I-60020 Torrette di Ancona, Italy

About: Alfredo Santinelli

Department of Pathology, University of Ancona, Ospedale Nuovo Regionale, I-60020 Torrette di Ancona, Italy

About: Mirca Valli

Department of Pathology, University of Ancona, Ospedale Nuovo Regionale, I-60020 Torrette di Ancona, Italy

About: Roberta Taborro

Department of Pathology, University of Ancona, Ospedale Nuovo Regionale, I-60020 Torrette di Ancona, Italy

About: Bruno Mannello

Department of Pathology, University of Ancona, Ospedale Nuovo Regionale, I-60020 Torrette di Ancona, Italy

About: Gianmario Mariuzzi

Department of Pathology, University of Verona, Policlinico Borgo Roma, I-37100 Verona, Italy