Acta Stereologica



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Lisbeth Regeur

Stereological quantitation of brains from demented and nondemented old females

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Neocortical volume, surface, and thickness and the volume of the ventricular system was estimated using unbiased stereological methods on brains from 28 old females (mean age 81.8 yrs) with increasing degree of senile dementia and compared with the same parameters on brains from 13 age-matched (mean age = 82.7 yrs) nondemented controls. Brains from the demented patients had decreased cortex volume. Neocortical thickness was significantly reduced in the demented patients with the highest degree of reduction in the most demented patients, while surface area not was changed. Furthermore ventricular volume was significantly increased in the demented patients.

Keywords : Cavalieri estimate, dementia, neocortical volume, stereology, surface, thickness

To cite this article

Lisbeth Regeur, «Stereological quantitation of brains from demented and nondemented old females», Acta Stereologica [En ligne], Volume 12 (1993), Number 2 - Proceedings of the sixth European congress for stereology - Part one - Dec. 1993, 311-315 URL :

About: Lisbeth Regeur

Neurological Research Laboratory, Bartholin Instituttet, Kommunehospitalet, Copenhagen, Denmark