Acta Stereologica

0351-580X

 

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Maria José , Artur Pereira, Manuel M. Paula-Barbosa & Maria Dulce Madeira

Anatomical asymmetries in the human hippocampal formation

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Abstract

Unbiased stereological methods were used to evaluate whether in humans there are right/left asymmetries in the morphology of the hippocampal formation. The quantitative parameters analyzed were the volume of the layers, the total number of neurons and the mean neuronal volume. In the dentate gyrus, the estimations were carried out in the granule cell layer and in the polymorphic layer (hilus); in the hippocampus proper they were undertaken in the pyramidal cell layers of the CA1 and CA3-2 fields. The analyses were performed in glycolmethacrylate-embedded sections, sampled using a systematic random procedure, from six right and six left hippocampal formations. The volume of the layers was estimated by applying the Principle of Cavalieri; the total number of neurons in each layer was estimated by means of the optical fractionator; the mean somatic and nuclear volumes of the granule, hilar and pyramidal neurons were estimated by using vertical sections and the nucleator" method.

The right hippocampal formation contained 20% more granule cells and 14% more CA3-2 pyramidal neurons than the left. No right/left asymmetries were found in the number of hilar and CA1 pyramidal cells. The volume of the cell-containing layers and of the hilus was similar in the right and left hippocampal formations. Likewise, no right/left differences were detected in the mean somatic and nuclear volumes of the granule, hilar and pyramidal neurons.

Keywords : asymmetry, hippocampal formation, human, neuronal numbers, vertical sections, volumes

To cite this article

Maria José , Artur Pereira, Manuel M. Paula-Barbosa & Maria Dulce Madeira, «Anatomical asymmetries in the human hippocampal formation», Acta Stereologica [En ligne], Number 2 - July 1999, Volume 18 (1999), 161-176 URL : https://popups.ulg.ac.be/0351-580x/index.php?id=171.

About: Maria José 

Department of Anatomy, Porto Medical School

About: Artur Pereira

Department of Anatomy, Porto Medical School

About: Manuel M. Paula-Barbosa

Department of Anatomy, Porto Medical School

About: Maria Dulce Madeira

Al. Hernâni Monteiro, 4200 Porto, Portugal