Acta Stereologica

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Brigitte Bo Andersen & Lise Korbo

Purkinje cell number and size, comparison of human and rat cerebella

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Abstract

Estimates of total number and mean volume of Purkinje cells in five human and nine rat cerebella were obtained using stereological methods based on unbiased principles and estimators. The average total number of Purkinje cells was 30.5106 (CV = SD/mean = 0.13) in humans and 0.61106 (CV = 0.21) in rats. Thus the total number of Purkinje cells was 50 times higher in the human compared with rats, while numerical density per mm3 was 13 times lower in humans (0.81103) compared with rats (10.1103). The nucleator was applied to estimate the number weighted mean volume of the large and unevenly distributed Purkinje cells. In humans the mean volume of Purkinje cell perikaryon is 14,250 μm3 (CV = 23%). The data are compared with the mean Purkinje cell perikaryon volume in rats, 5,300 μm3, with a CV of 5%. Expectedly, the variation in Purkinje perikaryon volume between individuals are larger in humans than the individual variation between rats.

Keywords : human, rat, cerebellum, number weighted mean volume, Purkinje cells

Pour citer cet article

Brigitte Bo Andersen & Lise Korbo, «Purkinje cell number and size, comparison of human and rat cerebella», Acta Stereologica [En ligne], Volume 12 (1993), Number 2 - Proceedings of the sixth European congress for stereology - Part one - Dec. 1993, 295-298 URL : http://popups.ulg.ac.be/0351-580X/index.php?id=4778.

A propos de : Brigitte Bo Andersen

Neurological Research Laboratory, Bartholin Instituttet, Kommunehospitalet, Copenhagen, Denmark

A propos de : Lise Korbo

Neurological Research Laboratory, Bartholin Instituttet, Kommunehospitalet, Copenhagen, Denmark